Chaperon Newsletters 2022 ****************************************************************************************** * ****************************************************************************************** Chaperon Newsletter No. 01/2022 Chaperon Newsletter No. 02/2022 Chaperon Newsletter No. 03/2022 Chaperon Newsletter No. 04/2022 Chaperon Newsletter No. 06/2022 Special Newsletter Chaperon Newsletter No. 08/2022 Chaperon Newsletter No. 09+10/2022 Chaperon Newsletter No. 11/2022 Chaperon Newsletter No. 12/2022 *========================================================================================= * Chaperon Newsletter No. 01/2022 *========================================================================================= New article co-authored by our team members Second primary cancers (SPCs) are clinically important as they may negatively influence pa or reveal important therapeutic side effects and general causes of cancer. Professor Hemmi professor Liska from our team contributed to an epidemiological study focusing on liver, g and bile duct cancer in this context (click for details). [ URL "http://chaperon.lfp.cuni. SecondPrimaryCancersAfterLiverGallbladderandBileDuctCancersandTheseCancersasSecondPrimaryC Picture of the month (new regular section of the newsletter) We have a new year and we would like to introduce to you the winners and participants of t 2021 in the form of a new section of the newsletter – the picture of the month. First mont We’re thus introducing the winner – Vladimira Moulisova (Faculty of Medicine in Pilsen) wi of decellularized porcine liver scaffold with growing endothelial cells (click for details chaperon.lfp.cuni.cz/NerdArtPrizePictureofthemonth"] Invitation The Chaperon project and Technology Center CAS invite all our Ph.D. students to a seminar opportunities for young researchers at FMP and News from the Department of Science and res February 3rd 2022, 13:00 – 15:00. More information available here [ URL "http://chaperon.l file_download/51/Grant+opportunities+for+young+researchers+at+FMP+and+News+from+the+Depart +3.2.2022.pdf"] *========================================================================================= * Chaperon Newsletter No. 02/2022 *========================================================================================= First Chaperon experimental article published Hepatocellular carcinoma (HCC) is one of the most common cancers in the world, which frequ recurs after the curative resection. Several options to predict recurrence of HCC have bee however, their prognostic ability is limited. More information could be found here.. [ URL chaperon.lfp.cuni.cz/FirstChaperonexperimentalarticlepublished"] PhD positions in Laboratory of Translational Cancer Genomics The Laboratory of Translational Cancer Genomics lead by Professor Kari Hemminki invites qu candidates to apply for a five Ph.D. positions in Cancer Research (Genomics, Transcriptomi Immunology). The application deadline is April 30, 2022. For more details read here.. [ UR chaperon.lfp.cuni.cz/PhDpositionsinLaboratoryofTranslationalCancerGenomics"] Introducing a new course for PhD students The new journal club-based course led by Dr. Phanindra Babu Kasi and called „MODERN TOPICS & LIFE SCIENCES“ is designed to be an accredited PhD course at the Doctoral Study (Ph.D.) Faculty of Medicine in Pilsen, Charles University. More information available here.. [ URL chaperon.lfp.cuni.cz/IntroducinganewcourseforPhDstudents"] Picture of the month We would like to introduce the winners and participants of the Nerd Art Prize like the pic month. Second month – Second place. Zuzana Varaliová (PhD student at 3LF UK in Prague, Dep Pathophysiology) won the 2nd place with her picture of endothelial cells. See more here.. chaperon.lfp.cuni.cz/NerdArtPrizePictureofthemonthFebruary"] Chaperon Twitter account We are pleased to announce the launch of our Twitter account [ URL "https://twitter.com/Ch We are delighted to invite you to follow us and get updates on news, seminars, and events Chaperon project team and cooperations! *========================================================================================= * Chaperon Newsletter No. 03/2022 *========================================================================================= New research paper: Incidence and survival in oral and pharyngeal cancers in Finland and S half century Cancers of the oral cavity and pharynx encompass a heterogeneous group of cancers for whic risk factors include smoking, alcohol consumption, and human papillomavirus (HPV) infectio influence is site-specific with HPV mainly influencing oropharyngeal cancer. A detailed ov been recently published in an article co-authored by our ERA Chair holder, prof. Hemminki chaperon.lfp.cuni.cz/IncidenceandsurvivalinoralandpharyngealcancersinFinlandandSwedenthrou Picture of the month Introducing the winners and participants of the Nerd Art Prize, we are glad to present ano of the month. In March it is the third place – a picture by Roshan Kumar Singh, doctoral s Experimental Surgery, Faculty of Medicine in Pilsen. See more here.. [ URL "http://chapero NerdArtPrizePictureofthemonthMarch"] Ph.D. positions in Laboratory of Translational Cancer Genomics The Laboratory of Translational Cancer Genomics led by Professor Kari Hemminki invites qua to apply for a five Ph.D. positions in Cancer Research (Genomics,Transcriptomics, and Immu application deadline is April 30, 2022. For more details read here.. [ URL "http://chapero PhDpositionsinLaboratoryofTranslationalCancerGenomics"] *========================================================================================= * Chaperon Newsletter No. 04/2022 *========================================================================================= Long-term incidence in hepatocellular carcinoma and intrahepatic bile duct cancer in Denma Norway, and Sweden, the role of Thorotrast? We analyzed long-term incidence trends in liver cancer (including hepatocellular carcinoma intrahepatic cholangiocarcinoma) to interpret the changes in terms of known risk factors a hypothesize that historical exposure to Thorotrast, a radiographic contrast medium emittin particle, has changed population rates. A detailed overview has been recently published in article co-authored by our ERA Chair holder, prof. Hemminki. [ URL "http://chaperon.lfp.cu LongtermincidenceinhepatocellularcarcinomaandintrahepaticbileductcancerinDenmarkFinlandNor Picture of the month Introducing the winners and participants of the Nerd Art Prize, we are glad to present ano the month. In April is it a picture by Tereza Fenclová, doctoral student at Faculty of Med Her picture is a microphotograph of testicular tissue of a mouse male exposed to bisphenol more here.. [ URL "http://chaperon.lfp.cuni.cz/NerdArtPrizePictureofthemonthApril"] Scientific Blind Dates The Chaperon ERA Research Club invites you to participate in our “Scientific Blind Dates” chaperon.lfp.cuni.cz/ TheChaperonERAResearchClubinvitesyoutoparticipateinourScientificBlindDatesEventforPhDstude event for PhD students at the Charles University. On 27th of May at 2 p.m., in the seminar Biomedical Center, Faculty of Medicine in Pilsen. If you want to practice your scientific skills together with your colleagues, register here.. [ URL "https://docs.google.com/forms e/1FAIpQLSf6Itoezh57CB9kyE9FiQ9DcdfO_Tc6EMIrCVfq6x24Mm56Xg/viewform"] *========================================================================================= * Chaperon Newsletter No. 06/2022 *========================================================================================= Summer School of Experimental Surgery 2022 - Invitation to the lectures The Chaperon ERA Research Club invites you to the lectures organized within the framework of the Summer School of Experimental Surgery 2022. You can listen to 7 interesting lecture by foreign and Czech speakers, leaflets for the lectures are attached. Registration isn’t necessary you are all welcome. See more here... [ URL "http://chaperon.lfp.cuni.cz/ SummerSchoolofExperimentalSurgery2022Invitationtothelectures"] Announcing Chaperon cancer research conference in Prague – save the date! To everyone interested in cancer research: please save the date of May 29th and 30th, 2023 international Chaperon cancer research conference will be held in Prague (New Town Hall). coming soon. Nerd Art Prize 2021 Award Ceremony On the 7th of June 2022, the award ceremony for Nerd Art Prize 2021 took place. This cerem last year due to the coronavirus pandemic. Professor Kari Hemminki presented prizes to all More information and photos from this ceremony can be found here... [ URL "http://chaperon NerdArtPrize2021AwardCeremony"] The Chaperon ERA Research Club invites you to participate in Nerd Art Prize 2022 The ERA Research Club invites you to participate in our Nerd Art Prize contest by sending picture. This year we have two separate categories: Science & Research and Freestyle (i.e. Entries can be anything from a regular photo to any kind of instrumental output or visuali The contest call is open to all Charles University students and employees. Submission dead 15, 2022. You can find more information about the competition here... [ URL "http://chaper NerdArtPrize"] Ranking of top scientists by Research.com Research.com has released the first edition of its ranking of the top scientists in variou and different fields of science. The ranking is based on the recognition of the scientific the scientists have published. Our scientists took the top positions, see more here... [ U chaperon.lfp.cuni.cz/RankingofTopScientistsbyResearchcom"] June in the sign of lectures June was rich in professional seminars. On June 8th we and the University of West Bohemia a seminar “Commercialization of Applied Research Results” where five speakers presented th practical experiences. Click here for more information. [ URL "http://chaperon.lfp.cuni.cz CommercializazionofAppliedResearchResults"] On June 28th, we held a seminar in cooperation with befriended foreign universities at "Th Reproductive Lab". The audience heard 3 interesting lectures from foreign guests. Photos f can be found in the gallery. [ URL "http://chaperon.lfp.cuni.cz/GalleryReproductiveLabMeet The last seminar called "Why Don't You Get a Job?" was dedicated especially to Ph.D. stude future career options. The seminar was held on June 29th and photos can be found, once aga Chaperon gallery. [ URL "http://chaperon.lfp.cuni.cz/GalleryPhDJobSeminar"] Picture of the month We would like to introduce the winners and participants of the Nerd Art Prize 2021 as the month. In June it is a picture by Ing. Hedvika Rimnacova, a doctoral student from the Biom Faculty of Medicine in Pilsen, Charles University. See more here... [ URL "http://chaperon NerdArtPrizePictureofthemonthJune"] New courses for PhD students brought to life with Chaperon We are glad to announce that the first three courses of Chaperon’s ERA Research Club for P students and young researchers are now permanently available in e-learning form on CUNI’s platform [ URL "https://dl1.cuni.cz/course/search.php?areaids=core_course-course&q=chapero For more information about these courses click here... [ URL "http://chaperon.lfp.cuni.cz/ NewcoursesforPHDstudentsbroughttolifewithChaperon"] *========================================================================================= * Special newsletter *========================================================================================= The Meeting of the Reproductive Lab The Chaperon ERA Research Club invites you to the event called simply The Meeting of Repro officially known as the Laboratory of Reproductive Medicine. On the 28th of June at 1:30 p seminar room of the Biomedical Center, Faculty of Medicine in Pilsen, to learn the latest and epigenetics of breast cancer. For more information, click here... [ URL "http://chaper TheChaperoninvitesyoutoparticipateinourThemeetingofreproductivelab"] Why Don’t You Get A Job? Another ERA Research Club event “Why Don’t You Get A Job?” focuses on CUNI’s PhD students them find and utilize employment opportunities in the private pharmaceutic and biotechnolo with the help of several commercially experienced speakers! So, dear PhD students, don’t m this event on the 29th of June at 3 p.m., in the seminar room of the Biomedical Center, Fa of Medicine in Pilsen. Click here for further information... [ URL "http://chaperon.lfp.cu TheChaperonERAResearchClubinvitesyoutoparticipateinourWhyDontYouGetaJobEventforPhDstudents *========================================================================================= * Chaperon Newsletter No. 08/2022 *========================================================================================= New research paper: CTNNB1 mutations, TERT polymorphism and CD8+ cell densities in resecte carcinoma are associated with longer time to recurrence Hepatocellular carcinoma (HCC) is a fatal disease characterized by early genetic alteratio telomerase reverse transcriptase promoter (TERTp) and ?-catenin (CTNNB1) genes, and immune activation in the tumor microenvironment. We found out that certain combination of genetic immune factors improve patients’ survival. This finding has been recently published in an of the Chaperon’s Laboratory of Translational Cancer Genomics. [ URL "http://chaperon.lfp. NewResearchpaperCTNNB1mutationsTERTpolymorphismandCD8celldensitiesinresectedhepatocellular International conference organized by the Chaperon project in cooperation with the Institu Experimental Medicine CAS Chaperon, in cooperation with the Institute of Experimental Medicine CAS, would like to in international conference “Current understanding of colorectal and pancreatic cancers”. The be held on May 29th and 30th, 2023, at the historical venue of the New Town Hall, Prague. available online at cucap.cz [ URL "https://www.cucap.cz/"] Invitation to a lecture by David Hughes We would like to invite you to a lecture „Exploring two aspects of colorectal cancer devel genetically determined BMI at different lifestages and gut barrier dysfunction“ by Dr. Dav the date of September 13th, 2022, (2:30 p.m.). You can read more about Dr. Hughes here… [ chaperon.lfp.cuni.cz/TheChaperonprojectinvitesyoutoalecturebyDrDavidHughes"] The Chaperon project invites you to participate in our Lab meeting After the vacation, it is time to restart the traditional Chaperon lab meetings. In Septem cordially invited to the meeting of the Laboratory of Quantitative Histology [ URL "http:/ plzen.cz/en/210-laboratory-of-quantitative-histology"]  headed by Prof. Zbynek Tonar, M.D. We’re looking forward to seeing you on September 23rd, 2022, at 1:30 p.m. More information chaperon.lfp.cuni.cz/TheChaperoninvitesyoutoparticipateinourLabmeeting"] Picture of the month Introducing the winners and participants of the Nerd Art Prize 2021 as the picture of the we’re glad to present the picture of in vitro mitosis by Maria Stefania Massaro from the L of Cancer Treatment and Tissue Regeneration, Biomedical Center, Faculty of Medicine in Pil University. See more here... [ URL "http://chaperon.lfp.cuni.cz/NerdArtPrizePictureofthemo *========================================================================================= * Chaperon Newsletter No. 09+10/2022 *========================================================================================= New research paper: Long-term incidence in hepatocellular carcinoma and intrahepatic bile Denmark, Finland, Norway and Sweden, role of Thorotrast? We analyzed long-term incidence trends in liver cancer (including hepatocellular carcinoma intrahepatic cholangiocarcinoma) with an aim to interpret the changes in terms of known ri and hypothesize that historical exposure to Thorotrast, a radiographic contrast medium emi particles, has changed population rates. The NORDCAN database was used to collect cancer r data from Denmark (DK), Finland (FI), Norway (NO) and Sweden (SE), which we used from 1953 FI and NO) and 1960 (SE) through 2019. Continue reading here… [ URL "http://chaperon.lfp.c NewResearchpaperLongtermincidenceinhepatocellularcarcinomaandintrahepaticbileductcancerinD Visit and seminar by Dr. David Hughes A working meeting of principal representatives of research groups, collaborating together international projects ERA Chair Chaperon and Inter-Cost, took place in Pilsen on Septembe On September 13, 2022, UniMeC hosted a very interesting lecture titled „Exploring two aspe cancer development: genetically determined BMI at different life stages and gut barrier dy was delivered by the distinguished guest of the meeting, Dr. David Hughes. Read more here… chaperon.lfp.cuni.cz/VisitandseminarbyDrDavidHughes"] The IX Congress of Hepatopancreatobiliary Surgery The IX Congress of Hepatopancreatobiliary Surgery [ URL "https://www.chirurgieplzen2022.cz in Pilsen on September 19-20. The congress was actively attended by prof. Kari Hemminki, t Chair holder, as well as by Dr. Ambrozkiewicz and Dr. Trailin from the Laboratory of Trans Genomics [ URL "http://www.biomedic-plzen.cz/en/589-laboratory-of-translational-cancer-gen information here… [ URL "http://chaperon.lfp.cuni.cz/TheIXCongressofHepatopancreatobiliary The 45th Symposium on Hormones and Cell Regulation On October 12-15, 2022, Kari Hemminki participated in the 45th Symposium on Hormones and C the topic “Sex and Signalling: the molecular basis of sex and gender medicine”, held in Mo France. Read more here… [ URL "http://chaperon.lfp.cuni.cz/The45thSymposiumonHormonesandCe Starting your journey with medical resources All CUNI staff, but especially Ph.D. students are cordially invited to participate in the course „Starting your journey with medical resources [ URL "http://chaperon.lfp.cuni.cz/ Startingyourjourneywithmedicalresourcesonlinecourse"] “, which will help them find, use an literature and information resources. The course will also help you understand the publish sure your work gets the attention it deserves. The course will be organized in three lesso November 16, 23, and 30, 2022, starting at 10 a.m. Registration is required (please regist forms.gle/5PVySmziUjMwCbhb7 [ URL "https://forms.gle/5PVySmziUjMwCbhb7"] ). Picture of the month Introducing the winners and participants of the Nerd Art Prize 2021 as the picture of the glad to present the picture of a mouse zygote by Iveta Valentová from the Faculty of Scien University. See more here... [ URL "http://chaperon.lfp.cuni.cz/NerdArtPrizePictureofthemo *========================================================================================= * Chaperon Newsletter No. 11/2022 *========================================================================================= New research paper: Long Non-Coding RNA and microRNA Interplay in Colorectal Cancer and Th Tumor Microenvironment We focus on the miRNA/lncRNA/protein regulatory axes, which are known to influence the imm response in colorectal cancer. A detailed overview has been recently published by the team Laboratory of translational cancer genomics. Continue reading here… [ URL "http://chaperon NewResearchpaperLongNonCodingRNAandmicroRNAInterplayinColorectalCancerandTheirEffectontheT Deutscher Krebskongress 2022 GERMAN CANCER CONGRESS Our ERA Chair Kari Hemminki attended the German Cancer Congress [ URL "https://www.deutsch krebskongress.de/english.html"] of 2022 and gave a presentation ‘Cancer of unknown primary (CUP)—search for the primary site’. More information here… [ URL "http://chaperon.lfp.cuni DeutscherKrebskongress2022GERMANCANCERCONGRESS"] Winners of Nerd Art Prize 2022 We are excited to announce the winners of this year’s Nerd Art Prize! This time in two cat and Freestyle. And the winners are (drumroll please)… Read more here… [ URL "http://chaper WinnersofNerdArtPrize2022"] Review day of Chaperon project The entire Chaperon project team met with the European Commision on 23 November for a revi package leaders prepared a few words about the successes of the project so far. In the nex expect the European Commission to comment on these achievements. Picture of the month We would like to introduce the winners and participants of the Nerd Art Prize as the pictu month. In November it is a picture of a decellularized porcine arteria by Lenka Červenková Biomedical Center, Faculty of Medicine in Pilsen, Charles University. See more here... [ U chaperon.lfp.cuni.cz/Pictureofthemonth"] *========================================================================================= * Chaperon Newsletter No. 12/2022 *========================================================================================= New review paper: Activated Hepatic Stellate Cells in Hepatocellular Carcinoma: Their Role Target for Future Therapies Hepatocellular carcinoma (HCC) is a global healthcare challenge, which affects more than 8 new cases every year. Activated hepatic stellate cells (aHSCs) remain the principal cells drive HCC onset and growth. aHSCs suppress the anti-tumor immune response through interact with different immune cells. A detailed overview has been recently published by the team o Laboratory of translational cancer genomics. Continue reading here… [ URL "http://chaperon NewReviewpaperActivatedHepaticStellateCellsinHepatocellularCarcinomaTheirRoleasaPotentialT Invitation to an ERC seminar We are preparing a seminar on ERC project calls led by prof. Zdeněk Strakoš. The seminar s interactive and tailored to the needs of those seriously interested in ERC – if you are on please get in touch with us so that we can include you in the planning of the seminar, whi to take place in the second half of January. More information here… [ URL "http://chaperon InvitationtoERCseminar"] Clinical Genetics of Cancer 2022 - Szczecin Our ERA Chair Kari Hemminki attended the conference Clinical Genetics of Cancer 2022 in Sz The Chaperon project offers free research consultations The Chaperon Project offers free research consultations within its ERA Research Club. Read "http://chaperon.lfp.cuni.cz/TheChaperonprojectoffersfreeresearchconsultations"] Picture of the month - December We would like to introduce the winners and participants of Nerd Art Prize 2021 as the pict In December it is a picture of human chromosomes by Dr. Pavel Dvořák from the Department o Faculty of Medicine in Pilsen, Charles University. See more here... [ URL "http://chaperon NerdArtPrizePictureofthemonthDecember"]